The Giamanco laboratory seeks to further understand the role of the D-type cyclins in mediating cell division in the developing mouse brain. This information will shed light on how disorders characterized by aberrant cell division manifest including megalencephaly and microcephaly. This project is carried out in collaboration with colleagues at Weill Cornell Medical College.
I am also interested in developing culture models in which we can more thoroughly study how perineuronal nets form. More specifically, I want to identify how the molecular constituents arrange at the cellular surface to form these enigmatic structures. This work involves collaborative efforts with Dr. Russell T. Matthews.
Students working in my laboratory will gain experience with the following techniques: maintaining and propagating immortalized cell lines, generating primary cultures, immunocytochemistry, and fluorescence microscopy.